Hemodynamic dysfunction in neonatal sepsis.
Pediatr Res
; 91(2): 413-424, 2022 01.
Article
in En
| MEDLINE
| ID: mdl-34819654
ABSTRACT
Cardiovascular disturbances are a frequent occurrence in neonatal sepsis. Preterm and term infants are particularly vulnerable due to the unique features of their cardiovascular function and reserve, compared to older children and adults. The clinical manifestations of neonatal sepsis are a product of the variable inflammatory pathways involved (warm vs. cold shock physiology), developmental state of the cardiovascular system, and hormonal responses. Targeted neonatal echocardiography has played an important role in advancing our knowledge, may help delineate specific hemodynamic phenotypes in real-time, and supports an individualized physiology-based management of sepsis-associated cardiovascular dysfunction. IMPACT Cardiovascular dysfunction is a common sequela of sepsis. This review aims to highlight the pathophysiological mechanisms involved in hemodynamic disturbance in neonatal sepsis, provide insights from targeted neonatal echocardiography-based clinical studies, and suggest its potential incorporation in day-to-day management.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Neonatal Sepsis
/
Hemodynamics
Limits:
Humans
/
Newborn
Language:
En
Journal:
Pediatr Res
Year:
2022
Document type:
Article
Affiliation country:
Canadá