Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity.
Int J Mol Sci
; 22(22)2021 Nov 09.
Article
in En
| MEDLINE
| ID: mdl-34830021
ABSTRACT
Original results are presented in the field of research that addresses the extension of the reaction of residue of acyl-thiosemicarbazide fixation on the structure of 5-nitrobenzimidazole by a sulphonic group. The aim of the study is the increase of new thiosemicarbazide derivatives' applicative potential in the field of biochemistry, with a wide range of medical applications. The newly obtained compounds were characterized by using elemental analysis and spectral analysis (FT-IR and 1H NMR). A study regarding the optimization of the chemical reactions was made. The performed in vitro biological tests confirmed the tuberculostatic activity of three newly obtained compounds against Mycobacterium tuberculosis.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Semicarbazides
/
Tuberculosis
/
Mycobacterium tuberculosis
/
Antitubercular Agents
Limits:
Humans
Language:
En
Journal:
Int J Mol Sci
Year:
2021
Document type:
Article
Affiliation country:
Rumanía