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Dabrafenib plus trametinib in patients with BRAFV600E-mutant low-grade and high-grade glioma (ROAR): a multicentre, open-label, single-arm, phase 2, basket trial.
Wen, Patrick Y; Stein, Alexander; van den Bent, Martin; De Greve, Jacques; Wick, Antje; de Vos, Filip Y F L; von Bubnoff, Nikolas; van Linde, Myra E; Lai, Albert; Prager, Gerald W; Campone, Mario; Fasolo, Angelica; Lopez-Martin, Jose A; Kim, Tae Min; Mason, Warren P; Hofheinz, Ralf-Dieter; Blay, Jean-Yves; Cho, Daniel C; Gazzah, Anas; Pouessel, Damien; Yachnin, Jeffrey; Boran, Aislyn; Burgess, Paul; Ilankumaran, Palanichamy; Gasal, Eduard; Subbiah, Vivek.
Affiliation
  • Wen PY; Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address: patrick_wen@dfci.harvard.edu.
  • Stein A; Department of Internal Medicine II (Oncology Center), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • van den Bent M; Brain Tumor Center and Department of Oncology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, Netherlands.
  • De Greve J; University Hospital Vrije Universiteit Brussel, Brussels, Belgium.
  • Wick A; Department of Neurology, University of Heidelberg, National Center for Tumor Diseases, Heidelberg, Germany.
  • de Vos FYFL; Department of Medical Oncology, University Medical Center Utrecht, University Utrecht, Utrecht, Netherlands.
  • von Bubnoff N; University Medical Center Freiburg, Freiburg, Germany; Department of Hematology and Oncology, Medical Center, University of Schleswig-Holstein, Lübeck, Germany.
  • van Linde ME; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam, Netherlands.
  • Lai A; Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
  • Prager GW; Department of Medicine I, AKH Wien, Medical University of Vienna, Vienna, Austria.
  • Campone M; Institut de Cancérologie de l'Ouest, Saint-Herblain, France.
  • Fasolo A; Department of Medical Oncology, Ospedale San Raffaele IRCCS, Milan, Italy.
  • Lopez-Martin JA; 12 de Octubre University Hospital & Research Institute, Madrid, Spain.
  • Kim TM; Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
  • Mason WP; University Health Network, University of Toronto, Toronto, ON, Canada.
  • Hofheinz RD; University Hospital of Mannheim, Mannheim, Germany.
  • Blay JY; Center Leon Berard & University Claude Bernard Lyon I, Lyon, France.
  • Cho DC; New York Medical College, Valhalla, New York, NY, USA.
  • Gazzah A; Gustave Roussy Cancer Institute, Villejuif, France.
  • Pouessel D; Department of Medical Oncology & Clinical Research Unit, Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France.
  • Yachnin J; Karolinska University Hospital, Theme Cancer, Center for Clinical Cancer Studies, Solna, Sweden.
  • Boran A; Global Drug Development, Oncology Development Unit, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA.
  • Burgess P; Global Drug Development, Oncology Development Unit, Novartis Pharma AG, Basel, Switzerland.
  • Ilankumaran P; Global Drug Development, Oncology Development Unit, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA.
  • Gasal E; Global Drug Development, Oncology Development Unit, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA.
  • Subbiah V; Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Lancet Oncol ; 23(1): 53-64, 2022 01.
Article in En | MEDLINE | ID: mdl-34838156
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Proto-Oncogene Proteins B-raf / Glioma / Mutation Type of study: Clinical_trials Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Lancet Oncol Journal subject: NEOPLASIAS Year: 2022 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Proto-Oncogene Proteins B-raf / Glioma / Mutation Type of study: Clinical_trials Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Lancet Oncol Journal subject: NEOPLASIAS Year: 2022 Document type: Article