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Relaxed Substrate Requirements of Sterol 14α-Demethylase from Naegleria fowleri Are Accompanied by Resistance to Inhibition.
Hargrove, Tatiana Y; Wawrzak, Zdzislaw; Rachakonda, Girish; Nes, W David; Villalta, Fernando; Guengerich, F Peter; Lepesheva, Galina I.
Affiliation
  • Hargrove TY; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
  • Wawrzak Z; Synchrotron Research Center, Life Science Collaborative Access Team, Northwestern University, Argonne, Illinois 60439, United States.
  • Rachakonda G; Department of Microbiology, Immunology and Physiology, Meharry Medical College, Nashville, Tennessee 37208, United States.
  • Nes WD; Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409, United States.
  • Villalta F; Department of Microbiology, Immunology and Physiology, Meharry Medical College, Nashville, Tennessee 37208, United States.
  • Guengerich FP; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
  • Lepesheva GI; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
J Med Chem ; 64(23): 17511-17522, 2021 12 09.
Article in En | MEDLINE | ID: mdl-34842434
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Naegleria fowleri / Sterol 14-Demethylase / 14-alpha Demethylase Inhibitors Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2021 Document type: Article Affiliation country: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Naegleria fowleri / Sterol 14-Demethylase / 14-alpha Demethylase Inhibitors Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2021 Document type: Article Affiliation country: Estados Unidos