Chiglitazar: First Approval.
Drugs
; 82(1): 87-92, 2022 Jan.
Article
in En
| MEDLINE
| ID: mdl-34846697
ABSTRACT
Chiglitazar (Bilessglu®) is an orally administered, non-thiazolidinedione small-molecule agonist of α, δ and γ peroxisome proliferator-activated receptors (PPARs) being developed by Chipscreen Biosciences for the treatment of type 2 diabetes (T2D) and non-alcoholic steatohepatitis. In October 2021, chiglitazar was approved in China for use as an adjunct to diet and exercise to improve glycaemic control in adult patients with T2D. The drug is also in phase 2 clinical development in China for the treatment of non-alcoholic steatohepatitis. This article summarizes the milestones in the development of chiglitazar leading to this first approval for the treatment of T2D.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Propionates
/
Carbazoles
/
Peroxisome Proliferator-Activated Receptors
/
Diabetes Mellitus, Type 2
/
Hypoglycemic Agents
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Drugs
Year:
2022
Document type:
Article
Affiliation country:
Nueva Zelanda