CTLA-4 Expression in Tumor-infiltrating Lymphocytes Is Irrelevant to PD-L1 Expression in NSCLC.
Anticancer Res
; 41(12): 6267-6272, 2021 Dec.
Article
in En
| MEDLINE
| ID: mdl-34848482
ABSTRACT
BACKGROUND/AIM:
Treatments containing ipilimumab have shown a good outcome in patients with non-small cell lung cancer (NSCLC) regardless of the PD-L1 tumor proportion score (TPS). However, the association between PD-L1 TPS and the expression of CTLA-4 in tumor-infiltrating lymphocytes is unknown. PATIENTS ANDMETHODS:
Fifty-five NSCLC patients who underwent surgery in our hospital were included in this study. We measured the proportions of CTLA-4+ regulatory T cells, and CTLA-4+ CD8 T cells, and statistically analyzed their correlations with the PD-L1 TPS.RESULTS:
Statistical correlations were found neither between the proportion of CTLA-4+ regulatory T cells to CD8 T cells and the PD-L1 TPS (p=0.2859) nor between the proportion of CTLA-4+ cells in CD8 T cells and the PD-L1 TPS (p=0.1919).CONCLUSION:
The proportions of CTLA-4+ regulatory T cells to CD8 T cells and CTLA-4+ cells in CD8 T cells were irrelevant to the PD-L1 TPS in NSCLC patients.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lymphocytes, Tumor-Infiltrating
/
Carcinoma, Non-Small-Cell Lung
/
B7-H1 Antigen
/
CTLA-4 Antigen
/
Lung Neoplasms
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
En
Journal:
Anticancer Res
Year:
2021
Document type:
Article
Affiliation country:
Japón