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A novel PDK1 inhibitor, JX06, inhibits glycolysis and induces apoptosis in multiple myeloma cells.
Kawano, Yawara; Sasano, Takayuki; Arima, Yuichiro; Kushima, Saki; Tsujita, Kenichi; Matsuoka, Masao; Hata, Hiroyuki.
Affiliation
  • Kawano Y; Department of Hematology, Rheumatology, and Infectious Diseases, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan. Electronic address: ykawanomn@kuh.kumamoto-u.ac.jp.
  • Sasano T; Division of Informative Clinical Sciences, Faculty of Medical Sciences, Kumamoto University, 4-24-1 Kuhonji, Chuo-ku, Kumamoto, 862-0976, Japan.
  • Arima Y; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan; International Research Center for Medical Sciences (IRCMS), Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto, 860-0811, Japan.
  • Kushima S; Division of Informative Clinical Sciences, Faculty of Medical Sciences, Kumamoto University, 4-24-1 Kuhonji, Chuo-ku, Kumamoto, 862-0976, Japan.
  • Tsujita K; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
  • Matsuoka M; Department of Hematology, Rheumatology, and Infectious Diseases, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
  • Hata H; Division of Informative Clinical Sciences, Faculty of Medical Sciences, Kumamoto University, 4-24-1 Kuhonji, Chuo-ku, Kumamoto, 862-0976, Japan.
Biochem Biophys Res Commun ; 587: 153-159, 2022 01 08.
Article in En | MEDLINE | ID: mdl-34875534
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Morpholines / Apoptosis / Disulfiram / Enzyme Inhibitors / Glycolysis / Antineoplastic Agents Limits: Humans Language: En Journal: Biochem Biophys Res Commun Year: 2022 Document type: Article Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Morpholines / Apoptosis / Disulfiram / Enzyme Inhibitors / Glycolysis / Antineoplastic Agents Limits: Humans Language: En Journal: Biochem Biophys Res Commun Year: 2022 Document type: Article Country of publication: Estados Unidos