Understanding neutropenia secondary to intrinsic or iatrogenic immune dysregulation.
Hematology Am Soc Hematol Educ Program
; 2021(1): 504-513, 2021 12 10.
Article
in En
| MEDLINE
| ID: mdl-34889406
ABSTRACT
As a key member of the innate and adaptive immune response, neutrophils provide insights into the hematopoietic and inflammatory manifestations of inborn errors of immunity (IEI) and the consequences of immunotherapy. The facile recognition of IEI presenting with neutropenia provides an avenue for hematologists to facilitate early diagnosis and expedite biologically rationale care. Moreover, enhancing the understanding of the molecular mechanisms driving neutropenia in IEI-decreased bone marrow reserves, diminished egress from the bone marrow, and decreased survival-offers an opportunity to further dissect the pathophysiology driving neutropenia secondary to iatrogenic immune dysregulation, eg, immune checkpoint inhibitors and chimeric antigen receptor T-cell therapy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Primary Immunodeficiency Diseases
/
Iatrogenic Disease
/
Immunotherapy
/
Neutropenia
Type of study:
Screening_studies
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Hematology Am Soc Hematol Educ Program
Journal subject:
HEMATOLOGIA
Year:
2021
Document type:
Article