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Synthesis and structure activity relationship of the first class of LXR inverse agonists.
Elgendy, Bahaa; Griffett, Kristine; Hegazy, Lamees; Di Fruscia, Paolo; Sample, Kirby; Schoepke, Emmalie; Kamenecka, Theodore M; Burris, Thomas P.
Affiliation
  • Elgendy B; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, MO 63110, USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Chemistry Department, Faculty of Science, Benha Unive
  • Griffett K; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, MO 63110, USA.
  • Hegazy L; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, MO 63110, USA.
  • Di Fruscia P; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom.
  • Sample K; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, MO 63110, USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Schoepke E; Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.
  • Kamenecka TM; The Scripps Research Institute, Scripps Florida, Department of Molecular Medicine, 130 Scripps Way #A2A, Jupiter, FL 33458, USA.
  • Burris TP; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, MO 63110, USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: tburris@wustl.edu.
Bioorg Chem ; 119: 105540, 2022 02.
Article in En | MEDLINE | ID: mdl-34902646
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Liver X Receptors / Heterocyclic Compounds, 4 or More Rings Limits: Humans Language: En Journal: Bioorg Chem Year: 2022 Document type: Article Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Liver X Receptors / Heterocyclic Compounds, 4 or More Rings Limits: Humans Language: En Journal: Bioorg Chem Year: 2022 Document type: Article Country of publication: Estados Unidos