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Intranasal immunization with a vaccinia virus vaccine vector expressing pre-fusion stabilized SARS-CoV-2 spike fully protected mice against lethal challenge with the heavily mutated mouse-adapted SARS2-N501Y MA30 strain of SARS-CoV-2.
Kibler, Karen V; Szczerba, Mateusz; Lake, Douglas; Roeder, Alexa J; Rahman, Masmudur; Hogue, Brenda G; Roy Wong, Lok-Yin; Perlman, Stanley; Li, Yize; Jacobs, Bertram L.
Affiliation
  • Kibler KV; Biodesign Center for Immunotherapy, Vaccines and Virotherapy, Arizona State University, Tempe, AZ, USA.
  • Szczerba M; Biodesign Center for Immunotherapy, Vaccines and Virotherapy, Arizona State University, Tempe, AZ, USA.
  • Lake D; School of Life Sciences, Arizona State University, Tempe, AZ, USA.
  • Roeder AJ; School of Life Sciences, Arizona State University, Tempe, AZ, USA.
  • Rahman M; Biodesign Center for Immunotherapy, Vaccines and Virotherapy, Arizona State University, Tempe, AZ, USA.
  • Hogue BG; Biodesign Center for Immunotherapy, Vaccines and Virotherapy, Arizona State University, Tempe, AZ, USA.
  • Roy Wong LY; School of Life Sciences, Arizona State University, Tempe, AZ, USA.
  • Perlman S; Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA.
  • Li Y; Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA.
  • Jacobs BL; Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA.
bioRxiv ; 2021 Dec 08.
Article in En | MEDLINE | ID: mdl-34909775
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: BioRxiv Year: 2021 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: BioRxiv Year: 2021 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos