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Loss of Sucrase-Isomaltase Function Increases Acetate Levels and Improves Metabolic Health in Greenlandic Cohorts.
Andersen, Mette K; Skotte, Line; Jørsboe, Emil; Polito, Ryan; Stæger, Frederik F; Aldiss, Peter; Hanghøj, Kristian; Waples, Ryan K; Santander, Cindy G; Grarup, Niels; Dahl-Petersen, Inger K; Diaz, Lars J; Overvad, Maria; Senftleber, Ninna K; Søborg, Bolette; Larsen, Christina V L; Lemoine, Clara; Pedersen, Oluf; Feenstra, Bjarke; Bjerregaard, Peter; Melbye, Mads; Jørgensen, Marit E; Færgeman, Nils J; Koch, Anders; Moritz, Thomas; Gillum, Matthew P; Moltke, Ida; Hansen, Torben; Albrechtsen, Anders.
Affiliation
  • Andersen MK; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Skotte L; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
  • Jørsboe E; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Section for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
  • Polito R; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Stæger FF; Section for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
  • Aldiss P; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Hanghøj K; Section for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
  • Waples RK; Section for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
  • Santander CG; Section for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
  • Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Dahl-Petersen IK; National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark; Steno Diabetes Center Copenhagen, Gentofte, Denmark.
  • Diaz LJ; Steno Diabetes Center Copenhagen, Gentofte, Denmark.
  • Overvad M; Steno Diabetes Center Copenhagen, Gentofte, Denmark.
  • Senftleber NK; Section for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark; Steno Diabetes Center Copenhagen, Gentofte, Denmark.
  • Søborg B; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
  • Larsen CVL; National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark; Greenland Centre for Health Research, University of Greenland, Nuuk, Greenland.
  • Lemoine C; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Feenstra B; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
  • Bjerregaard P; National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
  • Melbye M; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Medicine, Stanford University School of Medicine, Stanford, California.
  • Jørgensen ME; National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark; Steno Diabetes Center Copenhagen, Gentofte, Denmark; Greenland Centre for Health Research, University of Greenland, Nuuk, Greenland.
  • Færgeman NJ; Department of Biochemistry and Molecular Biology, Villum Center for Bioanalytical Sciences, University of Southern Denmark, Odense, Denmark.
  • Koch A; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark; Greenland Centre for Health Research, University of Greenland, Nuuk, Greenland; Department of Infectious Diseases, Rigshospitalet University Hospital, Copenhagen, Denmark.
  • Moritz T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Gillum MP; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Moltke I; Section for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark. Electronic address: ida@binf.ku.dk.
  • Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. Electronic address: torben.hansen@sund.ku.dk.
  • Albrechtsen A; Section for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark. Electronic address: albrecht@binf.ku.dk.
Gastroenterology ; 162(4): 1171-1182.e3, 2022 04.
Article in En | MEDLINE | ID: mdl-34914943
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sucrase-Isomaltase Complex / Dietary Sucrose Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Gastroenterology Year: 2022 Document type: Article Affiliation country: Dinamarca
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sucrase-Isomaltase Complex / Dietary Sucrose Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Gastroenterology Year: 2022 Document type: Article Affiliation country: Dinamarca