The efficacy and safety of neoadjuvant nimotuzumab for gastric cancer: A meta-analysis of randomized controlled studies.
Medicine (Baltimore)
; 100(50): e27709, 2021 12 17.
Article
in En
| MEDLINE
| ID: mdl-34918627
ABSTRACT
INTRODUCTION:
The efficacy of neoadjuvant nimotuzumab for gastric cancer remained controversial. We conducted a systematic review and meta-analysis to explore the efficacy of neoadjuvant nimotuzumab plus chemotherapy vs chemotherapy for gastric cancer.METHODS:
We have searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through May 2019, and included randomized controlled trials assessing the efficacy of neoadjuvant nimotuzumab plus chemotherapy vs chemotherapy for gastric cancer. This meta-analysis was performed using the random-effect model.RESULTS:
Four randomized controlled trials were included in the meta-analysis. There were 128 patients included in intervention group and 131 patients included in control group. Overall, compared with chemotherapy for gastric cancer, neoadjuvant nimotuzumab plus chemotherapy showed no substantial influence on response rate (risk ratio [RR]â=â1.22; 95% CIâ=â0.78-1.89; Pâ=â.38), disease control rate (RRâ=â2.22; 95% confidence interval [CI]â=â0.32-15.40; Pâ=â.42), rash (RRâ=â1.26; 95% CIâ=â0.96-1.66; Pâ=â.10), neutropenia (RRâ=â1.26; 95% CIâ=â0.96-1.66; Pâ=â.10), anemia (RRâ=â1.08; 95% CIâ=â0.62-1.89; Pâ=â.78), or nausea (RRâ=â1.19; 95% CIâ=â0.96-1.48; Pâ=â.12), but might improve the incidence of vomiting (RRâ=â1.60; 95% CIâ=â1.03-2.50; Pâ=â.04).CONCLUSIONS:
Neoadjuvant nimotuzumab might provide no additional benefits to the treatment of gastric cancer.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stomach Neoplasms
/
Neoadjuvant Therapy
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Antibodies, Monoclonal, Humanized
Type of study:
Clinical_trials
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Medicine (Baltimore)
Year:
2021
Document type:
Article
Affiliation country:
China
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
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US
/
USA