Ion-Depleting Action of Perm-Selective Membranes for Enhancing Electrical Communication and Gated Ion Channel Activity in Cell Cultures.
ACS Biomater Sci Eng
; 8(11): 4618-4621, 2022 11 14.
Article
in En
| MEDLINE
| ID: mdl-34932307
ABSTRACT
Ion-depletion action of an ion-selective membrane produces a moat channel that electrically insulates a cell colony and elevates the cell medium potential uniformly to synchronously activate and deactivate the voltage-gated ion channels of all cells. The result is robust synchronization with strong intercellular electrical communication and the discovery of ion channel deactivation that is only possible when the cells are in communication. The study suggests that the collective response of a cell colony to external stimuli is distinct from that of a single cell. Cell proliferation must hence be guided with strong intercellular communication and proper exogenous stimuli.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Culture Techniques
/
Ion Channels
Language:
En
Journal:
ACS Biomater Sci Eng
Year:
2022
Document type:
Article
Affiliation country:
Estados Unidos