Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier.
Science
; 374(6575): eabl5450, 2021 Dec 24.
Article
in En
| MEDLINE
| ID: mdl-34941394
ABSTRACT
Tissue-specific cues are critical for homeostasis at mucosal barriers. Here, we report that the clotting factor fibrin is a critical regulator of neutrophil function at the oral mucosal barrier. We demonstrate that commensal microbiota trigger extravascular fibrin deposition in the oral mucosa. Fibrin engages neutrophils through the αMß2 integrin receptor and activates effector functions, including the production of reactive oxygen species and neutrophil extracellular trap formation. These immune-protective neutrophil functions become tissue damaging in the context of impaired plasmin-mediated fibrinolysis in mice and humans. Concordantly, genetic polymorphisms in PLG, encoding plasminogen, are associated with common forms of periodontal disease. Thus, fibrin is a critical regulator of neutrophil effector function, and fibrin-neutrophil engagement may be a pathogenic instigator for a prevalent mucosal disease.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Periodontitis
/
Plasminogen
/
Fibrin
/
Neutrophil Activation
/
Mouth Mucosa
/
Neutrophils
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
En
Journal:
Science
Year:
2021
Document type:
Article
Affiliation country:
Estados Unidos