Current State of Carbohydrate Recognition and C-Type Lectin Receptors in Pneumocystis Innate Immunity.
Front Immunol
; 12: 798214, 2021.
Article
in En
| MEDLINE
| ID: mdl-34975910
ABSTRACT
Pneumocystis jirovecii is one of the most common fungal pathogens in immunocompromised individuals. Pneumocystis jirovecii pneumonia (PJP) causes a significant host immune response that is driven greatly by the organism's cell wall components including ß-glucans and major surface glycoprotein (Msg). These ligands interact with a number of C-type lectin receptors (CLRs) leading to downstream activation of proinflammatory signaling pathways. This minireview provides a brief overview summarizing known CLR/Pneumocystis interactions.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pneumonia, Pneumocystis
/
Fungal Proteins
/
Membrane Glycoproteins
/
Lectins, C-Type
/
Pneumocystis carinii
/
Beta-Glucans
/
Immunity, Innate
Limits:
Animals
/
Humans
Language:
En
Journal:
Front Immunol
Year:
2021
Document type:
Article
Affiliation country:
Estados Unidos