Evaluating systemic immune-inflammation index in patients with implantable cardioverter defibrillator for heart failure with reduced ejection fraction.
Pacing Clin Electrophysiol
; 45(2): 188-195, 2022 Feb.
Article
in En
| MEDLINE
| ID: mdl-34978742
ABSTRACT
BACKGROUND:
Pro-inflammatory pathways play an important role in the follow-ups of patients with intracardiac defibrillators (ICDs) for heart failure (HF) reduced with ejection fraction (HFrEF). A newly defined index - the systemic immune-inflammation index (SII)-has recently been reported to have prognostic value in patients with cardiovascular disease. This study's aim is to evaluate the SII value regarding its association with long-term mortality and appropriate ICD therapy during a 10-year follow-up.METHODS:
This retrospective study included 1011 patients with ICD for HFrEF. The SII was calculated as the neutrophil-to-lymphocyte ratio × total platelet count in the peripheral blood. The study population was divided into two groups according to the SII's optimal cut-off value to predict long-term mortality. The long-term prognostic impact of SII on these patients was evaluated regarding mortality and appropriate ICD therapy.RESULTS:
The patients with a higher SII (≥1119) had significantly higher long-term mortality and appropriate ICD therapy rates. After adjustment for all confounding factors, the long-term mortality rate was 5.1 for a higher SII. (95% CI 2.9-8.1). The long-term appropriate ICD therapy rate was 2.0 for a higher SII (95% CI 1.4-3.0).CONCLUSION:
SII may be an independent predictive marker for both long-term mortality and appropriate ICD therapy in patients with HFrEF.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stroke Volume
/
Defibrillators, Implantable
/
Heart Failure
/
Inflammation
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Pacing Clin Electrophysiol
Year:
2022
Document type:
Article
Affiliation country:
Turquía