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TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.
Nozal, Vanesa; Martínez-González, Loreto; Gomez-Almeria, Marta; Gonzalo-Consuegra, Claudia; Santana, Paula; Chaikuad, Apirat; Pérez-Cuevas, Eva; Knapp, Stefan; Lietha, Daniel; Ramírez, David; Petralla, Sabrina; Monti, Barbara; Gil, Carmen; Martín-Requero, Angeles; Palomo, Valle; de Lago, Eva; Martinez, Ana.
Affiliation
  • Nozal V; Centro de Investigaciones Biológicas Margarita Salas─CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain.
  • Martínez-González L; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28031 Madrid, Spain.
  • Gomez-Almeria M; Centro de Investigaciones Biológicas Margarita Salas─CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain.
  • Gonzalo-Consuegra C; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28031 Madrid, Spain.
  • Santana P; Instituto de Investigación en Neuroquímica, Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain.
  • Chaikuad A; Instituto de Investigación en Neuroquímica, Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain.
  • Pérez-Cuevas E; Facultad de Ingeniería, Instituto de Ciencias Químicas Aplicadas, Universidad Autónoma de Chile el Llano Subercaseaux, 2801 San Miguel, Santiago, Chile.
  • Knapp S; Institute for Pharmaceutical Chemistry, Goethe University Frankfurt, Max von Lauestrasse 9, 60438 Frankfurt, Germany.
  • Lietha D; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe University Frankfurt, Max von Lauestrasse 15, 60438 Frankfurt, Germany.
  • Ramírez D; Centro de Investigaciones Biológicas Margarita Salas─CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain.
  • Petralla S; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28031 Madrid, Spain.
  • Monti B; Institute for Pharmaceutical Chemistry, Goethe University Frankfurt, Max von Lauestrasse 9, 60438 Frankfurt, Germany.
  • Gil C; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe University Frankfurt, Max von Lauestrasse 15, 60438 Frankfurt, Germany.
  • Martín-Requero A; Centro de Investigaciones Biológicas Margarita Salas─CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain.
  • Palomo V; Departamento de Farmacología, Facultad de Ciencias Biológicas, Universidad de Concepción, Víctor Lamas 1290, PO Box 160-C, 1290 Concepción, Chile.
  • de Lago E; Department of Pharmacy and Biotechnology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy.
  • Martinez A; Department of Pharmacy and Biotechnology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy.
J Med Chem ; 65(2): 1585-1607, 2022 01 27.
Article in En | MEDLINE | ID: mdl-34978799
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Protein Serine-Threonine Kinases / Protein Kinase Inhibitors / DNA-Binding Proteins / Amyotrophic Lateral Sclerosis / Inflammation / Macrophages Type of study: Observational_studies / Risk_factors_studies Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: España
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Protein Serine-Threonine Kinases / Protein Kinase Inhibitors / DNA-Binding Proteins / Amyotrophic Lateral Sclerosis / Inflammation / Macrophages Type of study: Observational_studies / Risk_factors_studies Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: España