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Acazicolcept (ALPN-101), a dual ICOS/CD28 antagonist, demonstrates efficacy in systemic sclerosis preclinical mouse models.
Orvain, Cindy; Cauvet, Anne; Prudent, Alexis; Guignabert, Christophe; Thuillet, Raphaël; Ottaviani, Mina; Tu, Ly; Duhalde, Fanny; Nicco, Carole; Batteux, Frédéric; Avouac, Jérôme; Wang, NingXin; Seaberg, Michelle A; Dillon, Stacey R; Allanore, Yannick.
Affiliation
  • Orvain C; Université Paris Descartes, Sorbonne Paris Cité, INSERM U1016, Institut Cochin, CNRS UMR8104, Paris, France.
  • Cauvet A; Université Paris Descartes, Sorbonne Paris Cité, INSERM U1016, Institut Cochin, CNRS UMR8104, Paris, France.
  • Prudent A; Université Paris Descartes, Sorbonne Paris Cité, INSERM U1016, Institut Cochin, CNRS UMR8104, Paris, France.
  • Guignabert C; INSERM UMR_S 999, Le Plessis-Robinson, France.
  • Thuillet R; Université Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
  • Ottaviani M; INSERM UMR_S 999, Le Plessis-Robinson, France.
  • Tu L; Université Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
  • Duhalde F; INSERM UMR_S 999, Le Plessis-Robinson, France.
  • Nicco C; Université Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
  • Batteux F; INSERM UMR_S 999, Le Plessis-Robinson, France.
  • Avouac J; Université Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
  • Wang N; Université Paris Descartes, Sorbonne Paris Cité, INSERM U1016, Institut Cochin, CNRS UMR8104, Paris, France.
  • Seaberg MA; Université Paris Descartes, Sorbonne Paris Cité, INSERM U1016, Institut Cochin, CNRS UMR8104, Paris, France.
  • Dillon SR; Université Paris Descartes, Sorbonne Paris Cité, INSERM U1016, Institut Cochin, CNRS UMR8104, Paris, France.
  • Allanore Y; Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Universitaire Paris Centre (HUPC), Centre Hospitalier Universitaire (CHU) Cochin, Service d'immunologie biologique (Professeur Batteux), Paris, France.
Arthritis Res Ther ; 24(1): 13, 2022 01 05.
Article in En | MEDLINE | ID: mdl-34986869
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Scleroderma, Systemic / CD28 Antigens / Single-Chain Antibodies / Inducible T-Cell Co-Stimulator Protein Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Arthritis Res Ther Journal subject: REUMATOLOGIA Year: 2022 Document type: Article Affiliation country: Francia Country of publication: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Scleroderma, Systemic / CD28 Antigens / Single-Chain Antibodies / Inducible T-Cell Co-Stimulator Protein Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Arthritis Res Ther Journal subject: REUMATOLOGIA Year: 2022 Document type: Article Affiliation country: Francia Country of publication: Reino Unido