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Obatoclax inhibits SARS-CoV-2 entry by altered endosomal acidification and impaired cathepsin and furin activity in vitro.
Mao, Binli; Le-Trilling, Vu Thuy Khanh; Wang, Kai; Mennerich, Denise; Hu, Jie; Zhao, Zhenyu; Zheng, Jiaxin; Deng, Yingying; Katschinski, Benjamin; Xu, Shilei; Zhang, Guiji; Cai, Xuefei; Hu, Yuan; Wang, Jianwei; Lu, Mengji; Huang, Ailong; Tang, Ni; Trilling, Mirko; Lin, Yong.
Affiliation
  • Mao B; Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Institute for Viral Hepatitis, Chongqing Medical University, Chongqing, People's Republic of China.
  • Le-Trilling VTK; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
  • Wang K; Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Institute for Viral Hepatitis, Chongqing Medical University, Chongqing, People's Republic of China.
  • Mennerich D; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
  • Hu J; Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Institute for Viral Hepatitis, Chongqing Medical University, Chongqing, People's Republic of China.
  • Zhao Z; Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Institute for Viral Hepatitis, Chongqing Medical University, Chongqing, People's Republic of China.
  • Zheng J; Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Institute for Viral Hepatitis, Chongqing Medical University, Chongqing, People's Republic of China.
  • Deng Y; Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Institute for Viral Hepatitis, Chongqing Medical University, Chongqing, People's Republic of China.
  • Katschinski B; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
  • Xu S; Department of General Surgery, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China.
  • Zhang G; Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Institute for Viral Hepatitis, Chongqing Medical University, Chongqing, People's Republic of China.
  • Cai X; Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Institute for Viral Hepatitis, Chongqing Medical University, Chongqing, People's Republic of China.
  • Hu Y; Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Institute for Viral Hepatitis, Chongqing Medical University, Chongqing, People's Republic of China.
  • Wang J; Department of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing, People's Republic of China.
  • Lu M; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
  • Huang A; Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Institute for Viral Hepatitis, Chongqing Medical University, Chongqing, People's Republic of China.
  • Tang N; Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Institute for Viral Hepatitis, Chongqing Medical University, Chongqing, People's Republic of China.
  • Trilling M; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
  • Lin Y; Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Department of Infectious Diseases, The Second Affiliated Hospital, Institute for Viral Hepatitis, Chongqing Medical University, Chongqing, People's Republic of China.
Emerg Microbes Infect ; 11(1): 483-497, 2022 Dec.
Article in En | MEDLINE | ID: mdl-34989664
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Cathepsins / Furin / Virus Internalization / SARS-CoV-2 / Indoles Limits: Humans Language: En Journal: Emerg Microbes Infect Year: 2022 Document type: Article
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Cathepsins / Furin / Virus Internalization / SARS-CoV-2 / Indoles Limits: Humans Language: En Journal: Emerg Microbes Infect Year: 2022 Document type: Article