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Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency.
Reifschneider, Anika; Robinson, Sophie; van Lengerich, Bettina; Gnörich, Johannes; Logan, Todd; Heindl, Steffanie; Vogt, Miriam A; Weidinger, Endy; Riedl, Lina; Wind, Karin; Zatcepin, Artem; Pesämaa, Ida; Haberl, Sophie; Nuscher, Brigitte; Kleinberger, Gernot; Klimmt, Julien; Götzl, Julia K; Liesz, Arthur; Bürger, Katharina; Brendel, Matthias; Levin, Johannes; Diehl-Schmid, Janine; Suh, Jung; Di Paolo, Gilbert; Lewcock, Joseph W; Monroe, Kathryn M; Paquet, Dominik; Capell, Anja; Haass, Christian.
Affiliation
  • Reifschneider A; Division of Metabolic Biochemistry, Faculty of Medicine, Biomedical Center (BMC), Ludwig-Maximilians-Universität München, Munich, Germany.
  • Robinson S; Institute for Stroke and Dementia Research, University Hospital Munich, Ludwig-Maximilians-Universität München, Munich, Germany.
  • van Lengerich B; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.
  • Gnörich J; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Logan T; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.
  • Heindl S; Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Vogt MA; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Weidinger E; Institute for Stroke and Dementia Research, University Hospital Munich, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Riedl L; ISAR Bioscience GmbH, Planegg, Germany.
  • Wind K; Department of Neurology, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Zatcepin A; Department of Psychiatry and Psychotherapy, School of Medicine, Technical University of Munich, Munich, Germany.
  • Pesämaa I; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.
  • Haberl S; Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Nuscher B; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.
  • Kleinberger G; Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Klimmt J; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.
  • Götzl JK; ISAR Bioscience GmbH, Planegg, Germany.
  • Liesz A; Division of Metabolic Biochemistry, Faculty of Medicine, Biomedical Center (BMC), Ludwig-Maximilians-Universität München, Munich, Germany.
  • Bürger K; ISAR Bioscience GmbH, Planegg, Germany.
  • Brendel M; Institute for Stroke and Dementia Research, University Hospital Munich, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Levin J; Division of Metabolic Biochemistry, Faculty of Medicine, Biomedical Center (BMC), Ludwig-Maximilians-Universität München, Munich, Germany.
  • Diehl-Schmid J; Institute for Stroke and Dementia Research, University Hospital Munich, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Suh J; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
  • Di Paolo G; Institute for Stroke and Dementia Research, University Hospital Munich, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Lewcock JW; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.
  • Monroe KM; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.
  • Paquet D; Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Capell A; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.
  • Haass C; Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.
EMBO J ; 41(4): e109108, 2022 02 15.
Article in En | MEDLINE | ID: mdl-35019161
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / Monocytes / Receptors, Immunologic / Microglia / Frontotemporal Lobar Degeneration / Progranulins Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: EMBO J Year: 2022 Document type: Article Affiliation country: Alemania Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / Monocytes / Receptors, Immunologic / Microglia / Frontotemporal Lobar Degeneration / Progranulins Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: EMBO J Year: 2022 Document type: Article Affiliation country: Alemania Country of publication: Reino Unido