New prenylated flavonoid glycosides from the stems of Celastrus orbiculatus with their anti-tumor activities.
Nat Prod Res
; 37(9): 1463-1469, 2023 May.
Article
in En
| MEDLINE
| ID: mdl-35019806
ABSTRACT
Two new prenylated flavonoid glycosides (1-2), together with five known compounds (3-7) were isolated from the EtOAc-soluble extract of the stems of Celastrus orbiculatus. The structures of new compounds were elucidated with spectroscopic and physico-chemical analyses. All isolates were evaluated for in vitro cytotoxic activities against HepG2, MCF-7, A549, and A2780 cancer cells. Among them, compound 1 showed potential antiproliferative activity on A2780 cells with IC50 value of 10.76 µM. In addition, compound 2 exhibited selective cytotoxic activity on A2780 cells with IC50 value of 26.30 µM.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ovarian Neoplasms
/
Celastrus
/
Antineoplastic Agents
Limits:
Female
/
Humans
Language:
En
Journal:
Nat Prod Res
Year:
2023
Document type:
Article
Affiliation country:
China