Antiproliferative studies of transition metal chelates of a pyrazolone based hydrazone derivative.
J Biomol Struct Dyn
; 41(5): 1730-1744, 2023 03.
Article
in En
| MEDLINE
| ID: mdl-35021958
ABSTRACT
Pyrazolone derivatives play a significant role in the treatment of cancer. The synergic effect which emerges from the combination of pyrazolone moiety with hydrazone functionality was investigated. The objective of this study was to explore the antiproliferative potential of copper(II), cobalt(II), nickel(II) and zinc(II) metal chelates synthesized from pyrazolone based hydrazone derivative. The ligand and the metal chelates were characterized by various spectroscopic and analytical studies. The ligand was characterized by single crystal X-ray diffraction analysis.The results were in line with the spectroscopic methods. The geometry optimization of ligand and metal chelates were performed using density functional theory (DFT). The invitro cytotoxicity of ligand and metal chelates against different cancer cell lines was investigated by MTT assay. The cell-viability experiments showed that copper(II) complex is an efficient cytotoxic agent against HeLa cell line. Moreover, possible inhibition mechanism of synthesized compounds was evaluated in silico against HPV16-E6 receptor.Communicated by Ramaswamy H. Sarma.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyrazolones
/
Coordination Complexes
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Journal:
J Biomol Struct Dyn
Year:
2023
Document type:
Article
Affiliation country:
India