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The novel persistent sodium current inhibitor PRAX-562 has potent anticonvulsant activity with improved protective index relative to standard of care sodium channel blockers.
Kahlig, Kristopher M; Scott, Liam; Hatch, Robert J; Griffin, Andrew; Martinez Botella, Gabriel; Hughes, Zoë A; Wittmann, Marion.
Affiliation
  • Kahlig KM; Praxis Precision Medicines, Boston, Massachusetts, USA.
  • Scott L; Praxis Precision Medicines, Boston, Massachusetts, USA.
  • Hatch RJ; Praxis Precision Medicines, Boston, Massachusetts, USA.
  • Griffin A; Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia.
  • Martinez Botella G; Praxis Precision Medicines, Boston, Massachusetts, USA.
  • Hughes ZA; Praxis Precision Medicines, Boston, Massachusetts, USA.
  • Wittmann M; Praxis Precision Medicines, Boston, Massachusetts, USA.
Epilepsia ; 63(3): 697-708, 2022 03.
Article in En | MEDLINE | ID: mdl-35037706
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sodium Channel Blockers / Anticonvulsants Limits: Animals Language: En Journal: Epilepsia Year: 2022 Document type: Article Affiliation country: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sodium Channel Blockers / Anticonvulsants Limits: Animals Language: En Journal: Epilepsia Year: 2022 Document type: Article Affiliation country: Estados Unidos