Novel artful applications of vaccines at the horizon.
Pediatr Allergy Immunol
; 33 Suppl 27: 83-85, 2022 01.
Article
in En
| MEDLINE
| ID: mdl-35080298
ABSTRACT
Some live vaccines, particularly Bacillus Calmette-Guérin (BCG), oral polio vaccine (OPV), and measles vaccine, can reduce the incidence of all-cause mortality by outreaching the mere control of specific infections and exerting off-target effects. Asides from the prevention of viral infection, some other vaccines, such as those against flu or rotavirus, could reduce the risk of developing autoimmunity. The nonspecific effects of vaccines are mediated by the innate immune system, mainly through the so-called trained innate immunity. These observations paved the way for developing tolerogenic and trained immunity-based vaccines with substantial implications for more effective use of vaccines and combat vaccine hesitancy.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Virus Diseases
/
BCG Vaccine
Limits:
Humans
Language:
En
Journal:
Pediatr Allergy Immunol
Journal subject:
ALERGIA E IMUNOLOGIA
/
PEDIATRIA
Year:
2022
Document type:
Article
Affiliation country:
Italia