[Effect evaluation of surgical plus radio(chemo)therapy and non-surgery chemoradiotherapy treatment strategies for advanced tonsillar squamous cell carcinoma].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
; 57(1): 42-47, 2022 Jan 07.
Article
in Zh
| MEDLINE
| ID: mdl-35090208
ABSTRACT
Objective:
Using propensity score matching method(PSM) to investigate the clinical effect of surgical plus radio(chemo)therapy and non-surgery chemoradiotherapy treatment strategies for advanced tonsillar squamous cell carcinoma.Methods:
A retrospective analysis was conducted on the clinical data of 324 patients diagnosed with advanced tonsillar squamous cell carcinoma and treated in Peking Union Medical College Hospital from 2000 to 2018, confirmed by pathology and without distant metastasis. Survival analysis was performed using Kaplan-Meier estimates, the Cox proportional hazards model, and propensity score matching(PSM).Results:
Of the 324 patients, 102 were treated with non-surgery chemoradiotherapy treatment strategies and 222 with surgical plus radio(chemo)therapy treatment. Cox multivariate analysis showed that the non-surgery treatment group had a favorable prognosis than the surgical treatment group, however, these outcomes were not significantly different [overall survival(OS) adjusted Hazard Ratios(aHR) 0.92, 95% confidence interval(CI) 0.60-1.42; disease-specific survival(DSS) aHR 0.71, 95%CI 0.43-1.20; disease-free survival(DFS) aHR 0.82, 95%CI 0.53-1.28]. The new patient cohort consisted of 102 subpairs after PSM. There were no significant differences between two groups(OS aHR 0.85, 95%CI 0.51-1.40; DSS aHR 0.62, 95%CI 0.35-1.11; DFS aHR 0.80, 95%CI 0.49-1.33).Conclusion:
Our findings indicate that patients with non-surgical treatment do not have significantly better survival outcomes compared to surgical treatment group, while non-surgical treatment has advantages in improving the quality of life of patients, so comprehensive treatment based on radiotherapy and chemotherapy may be recommended for advanced tonsillar squamous cell carcinoma.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma, Squamous Cell
/
Tonsillar Neoplasms
Type of study:
Observational_studies
/
Prognostic_studies
Aspects:
Patient_preference
Limits:
Humans
Language:
Zh
Journal:
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
Year:
2022
Document type:
Article
Affiliation country:
China