Elevated constitutive expression of Hsp40 chaperone Sis1 reduces TDP-43 aggregation-induced oxidative stress in Ire1 pathway dependent-manner in yeast TDP-43 proteinopathy model of amyotrophic lateral sclerosis.

Bharathi, Vidhya; Bajpai, Akarsh; Parappuram, Irene T; Patel, Basant K

Bharathi, Vidhya; Bajpai, Akarsh; Parappuram, Irene T; Patel, Basant K.

Affiliation

Bharathi V; Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi, Sangareddy, Telangana, 502284, India.
Bajpai A; Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi, Sangareddy, Telangana, 502284, India.
Parappuram IT; Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi, Sangareddy, Telangana, 502284, India.
Patel BK; Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi, Sangareddy, Telangana, 502284, India. Electronic address: basantkpatel@bt.iith.ac.in.

Biochem Biophys Res Commun ; 595: 28-34, 2022 03 05.

Article in En | MEDLINE | ID: mdl-35093637

Subject(s)
Key words

ALS; Hsp40; Ire1; ROS; Sis1; TDP-43

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Saccharomyces cerevisiae / Membrane Glycoproteins / Protein Serine-Threonine Kinases / Oxidative Stress / Saccharomyces cerevisiae Proteins / HSP40 Heat-Shock Proteins / TDP-43 Proteinopathies / Amyotrophic Lateral Sclerosis Limits: Humans Language: En Journal: Biochem Biophys Res Commun Year: 2022 Document type: Article Affiliation country: India Country of publication: Estados Unidos

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