Bilateral Lung Transplant for Treatment of Idiopathic Pulmonary Fibrosis With Undetected Lung Adenocarcinoma: A Case Report.
Anticancer Res
; 42(2): 1157-1160, 2022 Feb.
Article
in En
| MEDLINE
| ID: mdl-35093920
ABSTRACT
BACKGROUND:
Lung transplant has become a curative therapy for various forms of progressive lung disease refractory to medical management. Idiopathic pulmonary fibrosis (IPF) is a rare condition characterized by accumulation of activated fibroblasts and secretion of extracellular matrices within the lung parenchyma. End-stage IPF is a fatal condition, with limited medical therapies other than lung transplantation. IPF has been demonstrated as a known risk factor for the development of lung cancer, and current lung transplant standards define history of malignancy within the past five years as an absolute exclusion criterion. CASE REPORT We present the case of a patient with biopsy-confirmed idiopathic pulmonary fibrosis treated with bilateral lung transplant, discovered to have stage four lung adenocarcinoma in the explanted lungs. The patient subsequently received pseudoadjuvant chemotherapy and remained recurrence-free until 23 months post-transplant.CONCLUSION:
This case highlights the challenge of ruling out malignancy in patients with end-stage lung disease. There remains a paucity of clinical studies on lung transplantation for lung cancer and more evidence is required before supporting this clinical decision.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lung Transplantation
/
Idiopathic Pulmonary Fibrosis
/
Adenocarcinoma of Lung
/
Lung Neoplasms
Type of study:
Diagnostic_studies
/
Guideline
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Humans
/
Male
Country/Region as subject:
America do norte
Language:
En
Journal:
Anticancer Res
Year:
2022
Document type:
Article
Affiliation country:
Canadá