Competitive blocking of LRP4-sclerostin binding interface strongly promotes bone anabolic functions.

Katchkovsky, Svetlana; Chatterjee, Biplab; Abramovitch-Dahan, Chen-Viki; Papo, Niv; Levaot, Noam

Katchkovsky, Svetlana; Chatterjee, Biplab; Abramovitch-Dahan, Chen-Viki; Papo, Niv; Levaot, Noam.

Affiliation

Katchkovsky S; Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 8410501, Beer-Sheva, Israel.
Chatterjee B; Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 8410501, Beer-Sheva, Israel.
Abramovitch-Dahan CV; Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 8410501, Beer-Sheva, Israel.
Papo N; Avram and Stella Goldstein-Goren Department of Biotechnology Engineering and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, 8410501, Beer-Sheva, Israel. papo@bgu.ac.il.
Levaot N; Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 8410501, Beer-Sheva, Israel. levaot@bgu.ac.il.

Cell Mol Life Sci ; 79(2): 113, 2022 Jan 31.

Article in En | MEDLINE | ID: mdl-35099616

Subject(s)
Key words

Bone formation; Drug targets; LRP4; LRP6; Sclerostin; Wnt pathway

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteogenesis / Recombinant Proteins / LDL-Receptor Related Proteins / Adaptor Proteins, Signal Transducing Limits: Animals / Female / Humans Language: En Journal: Cell Mol Life Sci Journal subject: BIOLOGIA MOLECULAR Year: 2022 Document type: Article Affiliation country: Israel Country of publication: Suiza

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