Immune Responses to Varicella-Zoster Virus Vaccines.
Curr Top Microbiol Immunol
; 438: 223-246, 2023.
Article
in En
| MEDLINE
| ID: mdl-35102438
ABSTRACT
The live attenuated varicella vaccine is intended to mimic the tempo and nature of the humoral and cell-mediated immune responses to varicella infection. To date, two doses of varicella vaccine administered in childhood have been very effective in generating varicella-zoster virus (VZV) immune responses that prevent natural infection for at least several decades. After primary infection, the infecting VZV establishes latency in sensory and cranial nerve ganglia with the potential to reactivate and cause herpes zoster. Although, the immune responses developed during varicella are important for preventing herpes zoster they wane with increasing age (immune senescence) or with the advent of immune suppression. Protection can be restored by increasing cell-mediated immune responses with two doses of an adjuvanted recombinant VZV glycoprotein E vaccine that stimulates both VZV-and gE-specific immunity. This vaccine provides ~85-90% protection against herpes zoster for 7-8 years (to date).
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chickenpox
/
Herpes Zoster Vaccine
/
Herpes Zoster
Limits:
Humans
Language:
En
Journal:
Curr Top Microbiol Immunol
Year:
2023
Document type:
Article
Affiliation country:
Estados Unidos