Chemical Components in Hedera rhombea Leaves and Their Cytotoxicity.
Chem Pharm Bull (Tokyo)
; 70(2): 175-181, 2022.
Article
in En
| MEDLINE
| ID: mdl-35110439
ABSTRACT
Two novel triterpene glycosides (1 and 2), 17 known triterpene glycosides (3-19), two known flavonoid glycosides (20 and 21), and two known norsesquiterpene glucosides (22 and 23) were isolated from Hedera rhombea (Araliaceae) leaves. The structures of 1 and 2 were determined by spectroscopic analysis, including two-dimensional NMR spectroscopy, and chromatographic analysis of the hydrolyzed products. The cytotoxicity of the isolated triterpene glycosides (1-19) against HL-60 human promyelocytic leukemia cells was evaluated. Compounds 9, 10, and 11 were cytotoxic to HL-60 cells with IC50 values of 7.2, 21.9, and 32.8 µM, respectively. Other compounds isolated from the leaves were not cytotoxic at sample concentrations of 50 µM.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Triterpenes
/
Plant Leaves
/
Araliaceae
/
Glycosides
/
Antineoplastic Agents, Phytogenic
Limits:
Humans
Language:
En
Journal:
Chem Pharm Bull (Tokyo)
Year:
2022
Document type:
Article