Unveiling idiopathic guttate hypomelanosis: pathology, immunohistochemistry, and ultrastructural study.
Int J Dermatol
; 61(8): 995-1002, 2022 Aug.
Article
in En
| MEDLINE
| ID: mdl-35114009
RESUMO
BACKGROUND: Idiopathic guttate hypomelanosis (IGH) is a pigment disorder of unknown etiology. Despite its high prevalence and the unaesthetic appearance of the lesions, there are relatively few histological studies on this disorder. This is an important gap to understanding its pathogenesis. OBJECTIVES: To assess the microscopic structure of IGH lesions compared to normal adjacent skin areas and the possible interaction between melanocytes and the subjacent dermis. METHODS: In this cross-sectional study, we took biopsy specimens of hypochromic lesions and adjacent normal skin from 20 patients with IGH. We analyzed the fragments using routine stains, immunohistochemistry, and electron microscopy. RESULTS: We found superficial dermal fibrosis in 90% (18/20) of our IGH cases and unreported keratinocyte cytoplasmic changes on electron microscopy. CONCLUSION: Our results suggest an interaction between melanocytes and the subjacent dermis in IGH. These findings can help to understand melanocyte biology and the pathogenesis of other achromic lesions.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pigmentation Disorders
/
Hypopigmentation
Type of study:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Int J Dermatol
Year:
2022
Document type:
Article
Affiliation country:
Brasil