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A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics.
Zhang, Li; Cheng, Chen; Li, Jing; Wang, Lili; Chumanevich, Alexander A; Porter, Donald C; Mindich, Aleksei; Gorbunova, Svetlana; Roninson, Igor B; Chen, Mengqian; McInnes, Campbell.
Affiliation
  • Zhang L; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, South Carolina 29208, United States.
  • Cheng C; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, South Carolina 29208, United States.
  • Li J; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, South Carolina 29208, United States.
  • Wang L; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, South Carolina 29208, United States.
  • Chumanevich AA; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, South Carolina 29208, United States.
  • Porter DC; Senex Biotechnology, Inc., Columbia, South Carolina 29208, United States.
  • Mindich A; CSC BIOCAD, Strelna, Saint-Petersburg 198515, Russia.
  • Gorbunova S; Biotechnology Department, Sirius University of Science and Technology, Sochi 354340, Russia.
  • Roninson IB; CSC BIOCAD, Strelna, Saint-Petersburg 198515, Russia.
  • Chen M; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, South Carolina 29208, United States.
  • McInnes C; Senex Biotechnology, Inc., Columbia, South Carolina 29208, United States.
J Med Chem ; 65(4): 3420-3433, 2022 02 24.
Article in En | MEDLINE | ID: mdl-35114084
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colonic Neoplasms / Cyclin-Dependent Kinases / Protein Kinase Inhibitors / Cyclin-Dependent Kinase 8 / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colonic Neoplasms / Cyclin-Dependent Kinases / Protein Kinase Inhibitors / Cyclin-Dependent Kinase 8 / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos