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Function of m6A and its regulation of domesticated animals' complex traits.
Mi, Siyuan; Shi, Yuanjun; Dari, Gerile; Yu, Ying.
Affiliation
  • Mi S; Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs and National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
  • Shi Y; Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs and National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
  • Dari G; Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs and National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
  • Yu Y; Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs and National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
J Anim Sci ; 100(3)2022 Mar 01.
Article in En | MEDLINE | ID: mdl-35137116
N6-methyladenosine (m6A) is the most abundant RNA modification in eukaryotes. Current studies showed that the m6A modification widely regulates a series of life processes, such as biological metabolism, growth and development, inflammation, and cancer. Understanding the m6A process of domestic animals can provide a new breakthrough for further promoting animal production performance and improving reproduction and disease resistance. Thus, this review briefly introduces m6A-related enzymes, m6A detection technologies, small-molecule inhibitors of m6A-related enzymes, and interaction between m6A and other biological progresses. In addition, the regulation mechanisms of m6A in domesticated animals' complex traits are elaborated and discussed.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Multifactorial Inheritance / Animals, Domestic Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Anim Sci Year: 2022 Document type: Article Affiliation country: China Country of publication: Estados Unidos

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Multifactorial Inheritance / Animals, Domestic Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Anim Sci Year: 2022 Document type: Article Affiliation country: China Country of publication: Estados Unidos