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N6-modification of 7-Deazapurine nucleoside analogues as Anti-Trypanosoma cruzi and anti-Leishmania agents: Structure-activity relationship exploration and In vivo evaluation.
Lin, Cai; Jaén Batista, Denise da Gama; Mazzeti, Ana Lia; Donola Girão, Roberson; de Oliveira, Gabriel Melo; Karalic, Izet; Hulpia, Fabian; Soeiro, Maria de Nazaré C; Maes, Louis; Caljon, Guy; Van Calenbergh, Serge.
Affiliation
  • Lin C; Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, Ottergemsesteenweg 460, B-9000, Gent, Belgium.
  • Jaén Batista DDG; Laboratório de Biologia Celular, Instituto Oswaldo Cruz (FIOCRUZ), Fundação Oswaldo Cruz, Rio de Janeiro, Avenida Brasil 4365, Manguinhos, 21040-360, Rio de Janeiro, Brazil.
  • Mazzeti AL; Laboratório de Biologia Celular, Instituto Oswaldo Cruz (FIOCRUZ), Fundação Oswaldo Cruz, Rio de Janeiro, Avenida Brasil 4365, Manguinhos, 21040-360, Rio de Janeiro, Brazil.
  • Donola Girão R; Laboratório de Biologia Celular, Instituto Oswaldo Cruz (FIOCRUZ), Fundação Oswaldo Cruz, Rio de Janeiro, Avenida Brasil 4365, Manguinhos, 21040-360, Rio de Janeiro, Brazil.
  • de Oliveira GM; Laboratório de Biologia Celular, Instituto Oswaldo Cruz (FIOCRUZ), Fundação Oswaldo Cruz, Rio de Janeiro, Avenida Brasil 4365, Manguinhos, 21040-360, Rio de Janeiro, Brazil.
  • Karalic I; Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, Ottergemsesteenweg 460, B-9000, Gent, Belgium.
  • Hulpia F; Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340, Beerse, Belgium.
  • Soeiro MNC; Laboratório de Biologia Celular, Instituto Oswaldo Cruz (FIOCRUZ), Fundação Oswaldo Cruz, Rio de Janeiro, Avenida Brasil 4365, Manguinhos, 21040-360, Rio de Janeiro, Brazil.
  • Maes L; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1, B-2610, Wilrijk, Belgium.
  • Caljon G; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1, B-2610, Wilrijk, Belgium.
  • Van Calenbergh S; Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, Ottergemsesteenweg 460, B-9000, Gent, Belgium. Electronic address: serge.vancalenbergh@ugent.be.
Eur J Med Chem ; 231: 114165, 2022 Mar 05.
Article in En | MEDLINE | ID: mdl-35144125
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trypanocidal Agents / Trypanosoma cruzi / Chagas Disease / Leishmania Limits: Animals Language: En Journal: Eur J Med Chem Year: 2022 Document type: Article Affiliation country: Bélgica Country of publication: Francia
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trypanocidal Agents / Trypanosoma cruzi / Chagas Disease / Leishmania Limits: Animals Language: En Journal: Eur J Med Chem Year: 2022 Document type: Article Affiliation country: Bélgica Country of publication: Francia