Oxidative DNA Damage and Cisplatin Neurotoxicity Is Exacerbated by Inhibition of OGG1 Glycosylase Activity and APE1 Endonuclease Activity in Sensory Neurons.

Behrouzi, Adib; Xia, Hanyu; Thompson, Eric L; Kelley, Mark R; Fehrenbacher, Jill C

Behrouzi, Adib; Xia, Hanyu; Thompson, Eric L; Kelley, Mark R; Fehrenbacher, Jill C.

Affiliation

Behrouzi A; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Xia H; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Thompson EL; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Kelley MR; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Fehrenbacher JC; Department of Pediatrics, Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Int J Mol Sci ; 23(3)2022 Feb 08.

Article in En | MEDLINE | ID: mdl-35163831

Subject(s)
Key words

DNA damage; base excision repair; chemotherapy-induced peripheral neuropathy; cisplatin; neurite outgrowth; neuropeptide; oxidative stress; sensory neuron

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Sensory Receptor Cells / Benzimidazoles / Cisplatin / DNA Glycosylases / DNA-(Apurinic or Apyrimidinic Site) Lyase / Ubiquitin-Protein Ligases Limits: Animals Language: En Journal: Int J Mol Sci Year: 2022 Document type: Article Affiliation country: Estados Unidos

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