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Fecal Signatures of Streptococcus anginosus and Streptococcus constellatus for Noninvasive Screening and Early Warning of Gastric Cancer.
Zhou, Cheng-Bei; Pan, Si-Yuan; Jin, Peng; Deng, Jia-Wen; Xue, Jin-Hui; Ma, Xin-Yue; Xie, Yuan-Hong; Cao, Hui; Liu, Qiang; Xie, Wei-Fen; Zou, Xiao-Ping; Sheng, Jian-Qiu; Wang, Bang-Mao; Wang, Hong; Ren, Jian-Lin; Liu, Si-De; Sun, Yun-Wei; Meng, Xiang-Jun; Zhao, Gang; Chen, Jin-Xian; Cui, Yun; Wang, Pei-Qin; Guo, Hui-Min; Yang, Lang; Chen, Xin; Ding, Jia; Yang, Xiao-Ning; Wang, Xin-Ke; Qian, Ai-Hua; Hou, Li-Dan; Wang, Zheng; Chen, Ying-Xuan; Fang, Jing-Yuan.
Affiliation
  • Zhou CB; Division of Gastroenterology and Hepatology; Shanghai Institute of Digestive Disease; NHC Key Laboratory of Digestive Diseases; State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
  • Pan SY; Division of Gastroenterology and Hepatology; Shanghai Institute of Digestive Disease; NHC Key Laboratory of Digestive Diseases; State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
  • Jin P; Department of Gastroenterology, The First Medical Center of Chinese People's Liberation Army General Hospital, The Seventh Medical Center of Chinese People's Liberation Army General Hospital, Beijing, China.
  • Deng JW; Division of Gastroenterology and Hepatology; Shanghai Institute of Digestive Disease; NHC Key Laboratory of Digestive Diseases; State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
  • Xue JH; Department of Clinical Research, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
  • Ma XY; Division of Gastroenterology and Hepatology; Shanghai Institute of Digestive Disease; NHC Key Laboratory of Digestive Diseases; State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
  • Xie YH; Division of Gastroenterology and Hepatology; Shanghai Institute of Digestive Disease; NHC Key Laboratory of Digestive Diseases; State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
  • Cao H; Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
  • Liu Q; Department of Pathology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
  • Xie WF; Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
  • Zou XP; Department of Gastroenterology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
  • Sheng JQ; Department of Gastroenterology, The First Medical Center of Chinese People's Liberation Army General Hospital, The Seventh Medical Center of Chinese People's Liberation Army General Hospital, Beijing, China.
  • Wang BM; Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin, China.
  • Wang H; Department of Gastroenterology, Shanghai Jing'an District Central Hospital, Fudan University, Shanghai, China.
  • Ren JL; Department of Gastroenterology, Zhongshan Hospital, Xiamen University, Xiamen, China.
  • Liu SD; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Sun YW; Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Meng XJ; Department of Gastroenterology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Zhao G; Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
  • Chen JX; Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
  • Cui Y; Division of Gastroenterology and Hepatology; Shanghai Institute of Digestive Disease; NHC Key Laboratory of Digestive Diseases; State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
  • Wang PQ; Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
  • Guo HM; Department of Gastroenterology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
  • Yang L; Department of Gastroenterology, The First Medical Center of Chinese People's Liberation Army General Hospital, The Seventh Medical Center of Chinese People's Liberation Army General Hospital, Beijing, China.
  • Chen X; Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin, China.
  • Ding J; Department of Gastroenterology, Shanghai Jing'an District Central Hospital, Fudan University, Shanghai, China.
  • Yang XN; Department of Gastroenterology, Zhongshan Hospital, Xiamen University, Xiamen, China.
  • Wang XK; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Qian AH; Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Hou LD; Department of Gastroenterology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Wang Z; Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address: wangzh1972@126.com.
  • Chen YX; Division of Gastroenterology and Hepatology; Shanghai Institute of Digestive Disease; NHC Key Laboratory of Digestive Diseases; State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address: yingxuanchen71
  • Fang JY; Division of Gastroenterology and Hepatology; Shanghai Institute of Digestive Disease; NHC Key Laboratory of Digestive Diseases; State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address: jingyuanfang@s
Gastroenterology ; 162(7): 1933-1947.e18, 2022 06.
Article in En | MEDLINE | ID: mdl-35167866
ABSTRACT
BACKGROUND &

AIMS:

Most patients with gastric cancer (GCa) are diagnosed at an advanced stage. We aimed to investigate novel fecal signatures for clinical application in early diagnosis of GCa.

METHODS:

This was an observational study that included 1043 patients from 10 hospitals in China. In the discovery cohort, 16S ribosomal RNA gene analysis was performed in paired samples (tissues and feces) from patients with GCa and chronic gastritis (ChG) to determine differential abundant microbes. Their relative abundances were detected using quantitative real-time polymerase chain reaction to test them as bacterial candidates in the training cohort. Their diagnostic efficacy was validated in the validation cohort.

RESULTS:

Significant enrichments of Streptococcus anginosus (Sa) and Streptococcus constellatus (Sc) in GCa tumor tissues (P < .05) and feces (P < .0001) were observed in patients with intraepithelial neoplasia, early and advanced GCa. Either the signature parallel test Sa∪Sc or single signature Sa/Sc demonstrated superior sensitivity (Sa 75.6% vs 72.1%, P < .05; Sc 84.4% vs 64.0%, P < .001; and Sa∪Sc 91.1% vs 81.4%, P < .01) in detecting early GCa compared with advanced GCa (specificity Sa 84.0% vs 83.9%, Sc 70.4% vs 82.3%, and Sa∪Sc 64.0% vs 73.4%). Fecal signature Sa∪Sc outperformed Sa∪CEA/Sc∪CEA in the discrimination of advanced GCa (sensitivity 81.4% vs 74.2% and 81.4% vs 72.3%, P < .01; specificity 73.4% vs 81.0 % and 73.4% vs 81.0%). The performance of Sa∪Sc in the diagnosis of both early and advanced GCa was verified in the validation cohort.

CONCLUSION:

Fecal Sa and Sc are noninvasive, accurate, and sensitive signatures for early warning in GCa. (ClinicalTrials.gov, Number NCT04638959).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms / Streptococcus constellatus Type of study: Diagnostic_studies / Observational_studies / Screening_studies Limits: Humans Language: En Journal: Gastroenterology Year: 2022 Document type: Article Affiliation country: China
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms / Streptococcus constellatus Type of study: Diagnostic_studies / Observational_studies / Screening_studies Limits: Humans Language: En Journal: Gastroenterology Year: 2022 Document type: Article Affiliation country: China