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LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains.
Weng, Jui-Hung; Aoto, Phillip C; Lorenz, Robin; Wu, Jian; Schmidt, Sven H; Manschwetus, Jascha T; Kaila-Sharma, Pallavi; Silletti, Steve; Mathea, Sebastian; Chatterjee, Deep; Knapp, Stefan; Herberg, Friedrich W; Taylor, Susan S.
Affiliation
  • Weng JH; Department of Pharmacology, University of California, San Diego, California, United States of America.
  • Aoto PC; Department of Pharmacology, University of California, San Diego, California, United States of America.
  • Lorenz R; Department of Biochemistry, University of Kassel, Kassel, Germany.
  • Wu J; Department of Pharmacology, University of California, San Diego, California, United States of America.
  • Schmidt SH; Department of Biochemistry, University of Kassel, Kassel, Germany.
  • Manschwetus JT; Department of Biochemistry, University of Kassel, Kassel, Germany.
  • Kaila-Sharma P; Department of Pharmacology, University of California, San Diego, California, United States of America.
  • Silletti S; Department of Chemistry and Biochemistry, University of California, San Diego, California, United States of America.
  • Mathea S; Institute for Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt am Main, Germany.
  • Chatterjee D; Institute for Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt am Main, Germany.
  • Knapp S; Institute for Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt am Main, Germany.
  • Herberg FW; Department of Biochemistry, University of Kassel, Kassel, Germany.
  • Taylor SS; Department of Pharmacology, University of California, San Diego, California, United States of America.
PLoS Biol ; 20(2): e3001427, 2022 02.
Article in En | MEDLINE | ID: mdl-35192607
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Conformation / Catalytic Domain / Molecular Dynamics Simulation / Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Limits: Humans Language: En Journal: PLoS Biol Journal subject: BIOLOGIA Year: 2022 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Conformation / Catalytic Domain / Molecular Dynamics Simulation / Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Limits: Humans Language: En Journal: PLoS Biol Journal subject: BIOLOGIA Year: 2022 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos