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Low-dose metformin targets the lysosomal AMPK pathway through PEN2.
Ma, Teng; Tian, Xiao; Zhang, Baoding; Li, Mengqi; Wang, Yu; Yang, Chunyan; Wu, Jianfeng; Wei, Xiaoyan; Qu, Qi; Yu, Yaxin; Long, Shating; Feng, Jin-Wei; Li, Chun; Zhang, Cixiong; Xie, Changchuan; Wu, Yaying; Xu, Zheni; Chen, Junjie; Yu, Yong; Huang, Xi; He, Ying; Yao, Luming; Zhang, Lei; Zhu, Mingxia; Wang, Wen; Wang, Zhi-Chao; Zhang, Mingliang; Bao, Yuqian; Jia, Weiping; Lin, Shu-Yong; Ye, Zhiyun; Piao, Hai-Long; Deng, Xianming; Zhang, Chen-Song; Lin, Sheng-Cai.
Affiliation
  • Ma T; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
  • Tian X; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
  • Zhang B; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
  • Li M; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
  • Wang Y; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
  • Yang C; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
  • Wu J; Laboratory Animal Research Centre, Xiamen University, Fujian, China.
  • Wei X; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
  • Qu Q; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
  • Yu Y; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
  • Long S; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
  • Feng JW; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
  • Li C; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
  • Zhang C; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
  • Xie C; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
  • Wu Y; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
  • Xu Z; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
  • Chen J; Analysis and Measurement Centre, School of Pharmaceutical Sciences, Xiamen University, Fujian, China.
  • Yu Y; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
  • Huang X; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
  • He Y; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
  • Yao L; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
  • Zhang L; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
  • Zhu M; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
  • Wang W; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Liaoning, China.
  • Wang ZC; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Liaoning, China.
  • Zhang M; Department of Endocrinology and Metabolism, Shanghai Clinical Centre for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
  • Bao Y; Department of Endocrinology and Metabolism, Shanghai Clinical Centre for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
  • Jia W; Department of Endocrinology and Metabolism, Shanghai Clinical Centre for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
  • Lin SY; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
  • Ye Z; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
  • Piao HL; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Liaoning, China.
  • Deng X; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China. xmdeng@xmu.edu.cn.
  • Zhang CS; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China. cszhang@xmu.edu.cn.
  • Lin SC; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China. linsc@xmu.edu.cn.
Nature ; 603(7899): 159-165, 2022 03.
Article in En | MEDLINE | ID: mdl-35197629
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vacuolar Proton-Translocating ATPases / Hypoglycemic Agents / Metformin Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nature Year: 2022 Document type: Article Affiliation country: China
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vacuolar Proton-Translocating ATPases / Hypoglycemic Agents / Metformin Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nature Year: 2022 Document type: Article Affiliation country: China