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The naturally occurring flavonoid nobiletin reverses methotrexate resistance via inhibition of P-glycoprotein synthesis.
Liu, Rui; Song, Yurong; Li, Chenxi; Zhang, Zhengjia; Xue, Zeyu; Huang, Qingcai; Yu, Liuchunyang; Zhu, Dongjie; Cao, Zhiwen; Lu, Aiping; Lu, Cheng; Liu, Yuanyan.
Affiliation
  • Liu R; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
  • Song Y; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
  • Li C; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
  • Zhang Z; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
  • Xue Z; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
  • Huang Q; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
  • Yu L; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
  • Zhu D; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
  • Cao Z; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
  • Lu A; School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hongkong, China. Electronic address: lap64067611@126.com.
  • Lu C; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China. Electronic address: lv_cheng0816@163.com.
  • Liu Y; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China. Electronic address: yyliu_1980@163.com.
J Biol Chem ; 298(4): 101756, 2022 04.
Article in En | MEDLINE | ID: mdl-35202652
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Experimental / Arthritis, Rheumatoid / Protein Biosynthesis / Drug Resistance / Flavones Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2022 Document type: Article Affiliation country: China Country of publication: Estados Unidos
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Experimental / Arthritis, Rheumatoid / Protein Biosynthesis / Drug Resistance / Flavones Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2022 Document type: Article Affiliation country: China Country of publication: Estados Unidos