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Effects of a local single dose administration of growth hormone on the osseointegration of titanium implants.
Grossi, J-R; Parra, M; Benalcázar-Jalkh, E-B; Giovanini, A-F; Zielak, J-C; Sebstiani, A-M; Gonzaga, C-C; Coelho, P-G; Witek, L; Deliberador, T-M.
Affiliation
  • Grossi JR; Division of Biomaterials New York University College of Dentistry 433 1st Avenue, Room 842 New York, NY 10010-4086 USA lukasz.witek@nyu.edu.
Med Oral Patol Oral Cir Bucal ; 27(2): e174-e180, 2022 Mar 01.
Article in En | MEDLINE | ID: mdl-35218646
ABSTRACT

BACKGROUND:

The aim of the present study was to evaluate the effect of different concentrations of growth hormone (GH) on endosteal implant's surface at the early stages of osseointegration. MATERIAL AND

METHODS:

Sixty tapered acid-etched titanium implants were divided into four groups i) Collagen, used as a control group; and three experimental groups, where after collagen coating, GH was administered directly to the surface in varying concentrations ii) 0.265 mg, iii) 0.53 mg, and iv) 1 mg. Implants were placed in an interpolated fashion in the anterior flange of C3, C4 or C5 of 15 sheep with minimum distance of 6 mm between implants. After 3-, 6- and 12-weeks of healing samples were harvested, histologically processed, qualitatively and quantitatively assessed for bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO).

RESULTS:

Statistical analysis as a function of time in vivo and coating resulted in no significant differences for BIC and BAFO at any evaluation time point. Histological evaluation demonstrated similar osseointegration features for all groups with woven bone formation at 3 weeks and progressive replacement of woven for lamellar bone in close contact with the implant surface and within the implant's threads.

CONCLUSIONS:

A single local application of growth hormone to the surface of titanium implants did not yield improved implant osseointegration independent of healing time.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dental Implants / Osseointegration Limits: Animals Language: En Journal: Med Oral Patol Oral Cir Bucal Journal subject: ODONTOLOGIA Year: 2022 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dental Implants / Osseointegration Limits: Animals Language: En Journal: Med Oral Patol Oral Cir Bucal Journal subject: ODONTOLOGIA Year: 2022 Document type: Article