pH-Sensitive Bioprobe for Multichannel Mitochondrial Imaging and Photodynamic Therapy.
Anal Chem
; 94(9): 4126-4133, 2022 03 08.
Article
in En
| MEDLINE
| ID: mdl-35220719
ABSTRACT
Tumor targeting therapy and photodynamic therapy are effective anti-cancer therapies. Their research progress has attracted wide attention and is one of the focuses of anti-cancer drug research and development. The design and synthesis of multifunctional organic phototheranostic agents for superior image-guided diagnosis and phototherapy play an increasingly positive role in cancer diagnosis and treatment. Herein, F16M and CyM were obtained through functional design from cyanine and F16. Physicochemical characterization and biological application results showed that CyM is a multifunctional organic biological probe, which can realize intracellular multichannel (green, yellow, red, and NIR) imaging, pH detection, and mitochondrial-targeted photodynamic therapy. As an organic phototheranostic agent, it could not only realize near-infrared imaging and photodynamic therapy in vivo and in vitro but also has excellent biocompatibility and good guiding significance for the development of multichannel imaging and mitochondrial-targeting photodynamic therapy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Photochemotherapy
/
Biosensing Techniques
/
Nanoparticles
Type of study:
Diagnostic_studies
Language:
En
Journal:
Anal Chem
Year:
2022
Document type:
Article