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DYRK1A suppression attenuates HIF­1α accumulation and enhances the anti­liver cancer effects of regorafenib and sorafenib under hypoxic conditions.
Zhang, Chong; Wu, Lin-Wen; Li, Zhi-Di; Zhang, Man-Man; Wu, Jie; Du, Fei-Hua; Zeng, Ling-Hui; Li, Yang-Ling.
Affiliation
  • Zhang C; Department of Pharmacology, School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang 310015, P.R. China.
  • Wu LW; Department of Pharmacology, School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang 310015, P.R. China.
  • Li ZD; Department of Pharmacology, School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang 310015, P.R. China.
  • Zhang MM; Department of Pharmacology, School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang 310015, P.R. China.
  • Wu J; School of Pharmaceutical and Materials Engineering and Institute for Advanced Studies, Taizhou University, Taizhou, Jiangsu 318000, P.R. China.
  • Du FH; Department of Pharmacology, School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang 310015, P.R. China.
  • Zeng LH; Department of Pharmacology, School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang 310015, P.R. China.
  • Li YL; Department of Clinical Pharmacology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, P.R. China.
Int J Oncol ; 60(4)2022 Apr.
Article in En | MEDLINE | ID: mdl-35244188
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylurea Compounds / Pyridines / Protein-Tyrosine Kinases / Protein Serine-Threonine Kinases / Hypoxia-Inducible Factor 1, alpha Subunit / Sorafenib / Liver Neoplasms / Hypoxia Limits: Humans Language: En Journal: Int J Oncol Journal subject: NEOPLASIAS Year: 2022 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylurea Compounds / Pyridines / Protein-Tyrosine Kinases / Protein Serine-Threonine Kinases / Hypoxia-Inducible Factor 1, alpha Subunit / Sorafenib / Liver Neoplasms / Hypoxia Limits: Humans Language: En Journal: Int J Oncol Journal subject: NEOPLASIAS Year: 2022 Document type: Article