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Contemporary advances in antibody-mediated encephalitis: anti-LGI1 and anti-Caspr2 antibody (Ab)-mediated encephalitides.
Seery, Nabil; Butzkueven, Helmut; O'Brien, Terence J; Monif, Mastura.
Affiliation
  • Seery N; Department of Neuroscience, Central Clinical School, Faculty of Medicine, Nursing and Health Science, Monash University, Melbourne, Victoria, Australia; Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia.
  • Butzkueven H; Department of Neuroscience, Central Clinical School, Faculty of Medicine, Nursing and Health Science, Monash University, Melbourne, Victoria, Australia; Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia.
  • O'Brien TJ; Department of Neuroscience, Central Clinical School, Faculty of Medicine, Nursing and Health Science, Monash University, Melbourne, Victoria, Australia; Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia.
  • Monif M; Department of Neuroscience, Central Clinical School, Faculty of Medicine, Nursing and Health Science, Monash University, Melbourne, Victoria, Australia; Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia; Department of Neurology, Royal Melbourne Hospital, Melbourne, Victoria, A
Autoimmun Rev ; 21(5): 103074, 2022 May.
Article in En | MEDLINE | ID: mdl-35247644
ABSTRACT
Encephalitides with antibodies directed against leucine-rich glioma-inactivated 1 (LGI1) and contactin-associated protein-like 2 (Caspr2) represent two increasingly well characterised forms of autoimmune encephalitis. Both share overlapping and distinct clinical features, are mediated by autoantibodies directed against differing proteins complexed with voltage-gated potassium channels, with unique genetic predisposition identified to date. Herein we summarise disease mechanisms, clinical features, treatment considerations, prognostic factors and clinical outcomes regarding these disorders.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Encephalitis / Glioma Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Autoimmun Rev Journal subject: ALERGIA E IMUNOLOGIA Year: 2022 Document type: Article Affiliation country: Australia
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Encephalitis / Glioma Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Autoimmun Rev Journal subject: ALERGIA E IMUNOLOGIA Year: 2022 Document type: Article Affiliation country: Australia