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Discovery, synthesis and evaluation of novel reversible monoacylglycerol lipase radioligands bearing a morpholine-3-one scaffold.
He, Yingfang; Gobbi, Luca C; Herde, Adrienne Müller; Rombach, Didier; Ritter, Martin; Kuhn, Bernd; Wittwer, Matthias B; Heer, Dominik; Hornsperger, Benoit; Bell, Charles; O'Hara, Fionn; Benz, Jörg; Honer, Michael; Keller, Claudia; Collin, Ludovic; Richter, Hans; Schibli, Roger; Grether, Uwe; Mu, Linjing.
Affiliation
  • He Y; Center for Radiopharmaceutical Sciences, Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland.
  • Gobbi LC; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, CH-4070 Basel, Switzerland.
  • Herde AM; Center for Radiopharmaceutical Sciences, Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland.
  • Rombach D; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, CH-4070 Basel, Switzerland.
  • Ritter M; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, CH-4070 Basel, Switzerland.
  • Kuhn B; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, CH-4070 Basel, Switzerland.
  • Wittwer MB; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, CH-4070 Basel, Switzerland.
  • Heer D; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, CH-4070 Basel, Switzerland.
  • Hornsperger B; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, CH-4070 Basel, Switzerland.
  • Bell C; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, CH-4070 Basel, Switzerland.
  • O'Hara F; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, CH-4070 Basel, Switzerland.
  • Benz J; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, CH-4070 Basel, Switzerland.
  • Honer M; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, CH-4070 Basel, Switzerland.
  • Keller C; Center for Radiopharmaceutical Sciences, Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland.
  • Collin L; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, CH-4070 Basel, Switzerland.
  • Richter H; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, CH-4070 Basel, Switzerland.
  • Schibli R; Center for Radiopharmaceutical Sciences, Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland.
  • Grether U; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, CH-4070 Basel, Switzerland.
  • Mu L; Center for Radiopharmaceutical Sciences, Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland; Department of Nuclear Medicine, University Hospital Zurich, CH-8091 Zurich, Switzerland. Electronic address: linjing.mu@pharma.ethz
Nucl Med Biol ; 108-109: 24-32, 2022.
Article in En | MEDLINE | ID: mdl-35248850
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Positron-Emission Tomography / Monoacylglycerol Lipases Limits: Animals Language: En Journal: Nucl Med Biol Journal subject: BIOLOGIA / MEDICINA NUCLEAR Year: 2022 Document type: Article Affiliation country: Suiza
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Positron-Emission Tomography / Monoacylglycerol Lipases Limits: Animals Language: En Journal: Nucl Med Biol Journal subject: BIOLOGIA / MEDICINA NUCLEAR Year: 2022 Document type: Article Affiliation country: Suiza