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Diagnosis and management of neutropenia in children: The approach of the Study Group on Neutropenia and Marrow Failure Syndromes of the Pediatric Italian Hemato-Oncology Association (Associazione Italiana Emato-Oncologia Pediatrica - AIEOP).
Fioredda, Francesca; Onofrillo, Daniela; Farruggia, Piero; Barone, Angelica; Veltroni, Marinella; Notarangelo, Lucia Dora; Menna, Giuseppe; Russo, Giovanna; Martire, Baldassarre; Finocchi, Andrea; Verzegnassi, Federico; Bonanomi, Sonia; Ramenghi, Ugo; Pillon, Marta; Dufour, Carlo.
Affiliation
  • Fioredda F; Unit of Haematology, IRCCS - Istituto Giannina Gaslini, Genoa, Italy.
  • Onofrillo D; Pediatric Hematology and Oncology Unit, Department of Hematology, Spirito Santo Hospital, Pescara, Italy.
  • Farruggia P; Department of Pediatric Onco-Hematology, University Hospital, Parma, Italy.
  • Barone A; Pediatric Hematology and Oncology Unit, ARNAS (Azienda di Rilievo Nazionale ad Alta Specializzazione) Ospedale Civico, Palermo, Italy.
  • Veltroni M; Department of Pediatric Onco-Hematology, Meyer Children's Hospital, Florence, Italy.
  • Notarangelo LD; Oncology-Haematology and Bone Marrow Transplantation Unit, Children's Hospital, Brescia, Italy.
  • Menna G; AORN (Azienda Ospedaliera Rilievo Nazionale), Santobono Pausillipon, Naples, Italy.
  • Russo G; Pediatric Ematologi and Oncology Unit, Azienda Policlinico-Vittorio Emanuele, University of Catania, Catania, Italy.
  • Martire B; Unit of Pediatrics and Neonatology, "Monsignor Dimiccoli" Hospital, Barletta, Italy.
  • Finocchi A; Unit of Immune and Infectious Disease, University Department of Pediatrics DPUO, Children's Hospital Bambino Gesù, IRCCS, Rome, Italy.
  • Verzegnassi F; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
  • Bonanomi S; Institute of Maternal and Child Health, IRCCS Burlo Garofalo, Trieste, Italy.
  • Ramenghi U; Department of Pediatric Hematology, San Gerardo Hospital, Monza, Italy.
  • Pillon M; MBBM (Monza e Brianza per Bambino e Mamma) Foundation, Department of Pediatrics, University of Milano - Bicocca, Monza, Italy.
  • Dufour C; Department of Pediatric and Public Health Sciences, University of Torino, Turin, Italy.
Pediatr Blood Cancer ; 69(6): e29599, 2022 06.
Article in En | MEDLINE | ID: mdl-35253359
ABSTRACT
Neutropenia refers to a group of diseases characterized by a reduction in neutrophil levels below the recommended age threshold. The present study aimed to review the diagnosis and management of neutropenia, including a diagnostic toolkit and candidate underlying genes. This study also aimed to review the progress toward the definition of autoimmune and idiopathic neutropenia rising in infancy or in late childhood but without remission, and provide suggestions for efficient diagnostics, including indications for the bone marrow and genetic testing. The management and treatment protocols for common and unique presentations are also reviewed, providing evidence tailored to a single patient.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone Marrow / Neutropenia Type of study: Diagnostic_studies / Guideline / Risk_factors_studies Limits: Child / Humans Country/Region as subject: Europa Language: En Journal: Pediatr Blood Cancer Journal subject: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Year: 2022 Document type: Article Affiliation country: Italia
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone Marrow / Neutropenia Type of study: Diagnostic_studies / Guideline / Risk_factors_studies Limits: Child / Humans Country/Region as subject: Europa Language: En Journal: Pediatr Blood Cancer Journal subject: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Year: 2022 Document type: Article Affiliation country: Italia