Prevalence and Clinical Significance of Helicobacter Pylori-negative Chronic Gastritis in Children.
J Pediatr Gastroenterol Nutr
; 74(5): 949-955, 2022 05 01.
Article
in En
| MEDLINE
| ID: mdl-35258500
ABSTRACT
OBJECTIVES:
The clinical significance of Helicobacter pylori-negative chronic gastritis (HPNCG) in children is unclear. We examined this issue in patients who had undergone esophagogastroduodenoscopy with systematic gastric sampling.METHODS:
Data of 1178 consecutive children who underwent diagnostic esophagogastroduodenoscopy were collected. Baseline characteristics and long-term outcomes were compared between children with active and inactive HPNCG and those with normal gastric histology. Follow-up data were available for up to 13âyears.RESULTS:
Altogether 24 (2.0%) children had active and 235 (19.9%) inactive HPNCG, 27 (2.3%) were Hpylori-positive, 46 (3.9%) had other gastric pathology, and 846 (71.8%) normal histology. Diarrhea (31.3% vs 25.1%, Pâ =â0.033), poor growth (23.6% vs 14.7%, Pâ <â0.001), bloody stools (13.9% vs 7.2%, Pâ<â0.001), anemia (46.5% vs 23.4%, Pâ<â0.001), hypersedimentation (39.7% vs 21.4%, Pâ<â0.001), hypoalbuminemia (40.4% vs 16.2%, Pâ<â0.001), and elevated fecal calprotectin (62.4% vs 31.5%, Pâ<â0.001) were more common and heartburn (13.9% vs 22.9%, Pâ=â0.002) less common in the HPNCG group than in the controls. Both active (OR 3.64,95% CI 1.35-9.82) andinactive (2.98, 2.18-4.08) HPNCG predicted a diagnosis in the initial investigations. Crohn disease (41.7%) was the most common diagnosis in active HPNCG and celiac disease (37.4%) in inactive HPNCG. During follow-up, 7 (9.9%) of the 71 initially nondiagnosed HPNCG children received a diagnosis.CONCLUSIONS:
HPNCG is a frequent finding in children undergoing EGD, the active form being associated especially with Crohn disease and the inactive with celiac disease. The long-term prognosis of patients with HPNCG who do not receive an initial diagnosis is good.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Crohn Disease
/
Celiac Disease
/
Helicobacter pylori
/
Helicobacter Infections
/
Gastritis
Type of study:
Diagnostic_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Child
/
Humans
Language:
En
Journal:
J Pediatr Gastroenterol Nutr
Year:
2022
Document type:
Article
Affiliation country:
Finlandia