AAV-Mediated Artificial miRNA Reduces Pathogenic Polyglucosan Bodies and Neuroinflammation in Adult Polyglucosan Body and Lafora Disease Mouse Models.

Gumusgoz, Emrah; Kasiri, Sahba; Guisso, Dikran R; Wu, Jun; Dear, Matthew; Verhalen, Brandy; Minassian, Berge A

Gumusgoz, Emrah; Kasiri, Sahba; Guisso, Dikran R; Wu, Jun; Dear, Matthew; Verhalen, Brandy; Minassian, Berge A.

Affiliation

Gumusgoz E; Division of Neurology, Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390, USA.
Kasiri S; Division of Neurology, Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390, USA.
Guisso DR; Division of Neurology, Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390, USA.
Wu J; Division of Neurology, Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390, USA.
Dear M; Division of Neurology, Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390, USA.
Verhalen B; Division of Neurology, Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390, USA.
Minassian BA; Present affiliation: Corteva Agriscience, Johnston, IA, 50131, USA.

Neurotherapeutics ; 19(3): 982-993, 2022 04.

Article in En | MEDLINE | ID: mdl-35347645

Subject(s)
Key words

AAV9; APBD; EPM2A; EPM2B; GBE1; GYS1; RNAi; miRNA

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lafora Disease / MicroRNAs Limits: Animals Language: En Journal: Neurotherapeutics Journal subject: NEUROLOGIA Year: 2022 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google