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Effect of a Ketohexokinase Inhibitor (PF-06835919) on In Vivo OATP1B Activity: Integrative Risk Assessment Using Endogenous Biomarker and a Probe Drug.
Tess, David A; Kimoto, Emi; King-Ahmad, Amanda; Vourvahis, Manoli; Rodrigues, A David; Bergman, Arthur; Qui, Ruolun; Somayaji, Veena; Weng, Yan; Fonseca, Kari R; Litchfield, John; Varma, Manthena V S.
Affiliation
  • Tess DA; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Worldwide Research & Development, Pfizer Inc, Cambridge, Massachusetts, USA.
  • Kimoto E; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Worldwide Research & Development, Pfizer Inc., Groton, Connecticut, USA.
  • King-Ahmad A; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Worldwide Research & Development, Pfizer Inc., Groton, Connecticut, USA.
  • Vourvahis M; Clinical Pharmacology, Global Product Development, Pfizer Inc, New York, New York, USA.
  • Rodrigues AD; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Worldwide Research & Development, Pfizer Inc., Groton, Connecticut, USA.
  • Bergman A; Clinical Pharmacology, Early Clinical Development, Pfizer Inc., Cambridge, Massachusetts, USA.
  • Qui R; Clinical Pharmacology, Early Clinical Development, Pfizer Inc., Cambridge, Massachusetts, USA.
  • Somayaji V; Clinical Biostatistics, Early Clinical Development, Pfizer Inc, Cambridge, Massachusetts, USA.
  • Weng Y; Clinical Pharmacology, Early Clinical Development, Pfizer Inc., Cambridge, Massachusetts, USA.
  • Fonseca KR; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Worldwide Research & Development, Pfizer Inc, Cambridge, Massachusetts, USA.
  • Litchfield J; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Worldwide Research & Development, Pfizer Inc, Cambridge, Massachusetts, USA.
  • Varma MVS; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Worldwide Research & Development, Pfizer Inc., Groton, Connecticut, USA.
Clin Pharmacol Ther ; 112(3): 605-614, 2022 09.
Article in En | MEDLINE | ID: mdl-35355249
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fructokinases Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Clin Pharmacol Ther Year: 2022 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fructokinases Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Clin Pharmacol Ther Year: 2022 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos