Evolution and diversification of mitochondrial protein import systems.
Curr Opin Cell Biol
; 75: 102077, 2022 04.
Article
in En
| MEDLINE
| ID: mdl-35390639
ABSTRACT
More than 95% of mitochondrial proteins are encoded in the nucleus, synthesised in the cytosol and imported into the organelle. The evolution of mitochondrial protein import systems was therefore a prerequisite for the conversion of the α-proteobacterial mitochondrial ancestor into an organelle. Here, I review that the origin of the mitochondrial outer membrane import receptors can best be understood by convergent evolution. Subsequently, I discuss an evolutionary scenario that was proposed to explain the diversification of the inner membrane carrier protein translocases between yeast and mammals. Finally, I illustrate a scenario that can explain how the two specialised inner membrane protein translocase complexes found in most eukaryotes were reduced to a single multifunctional one in trypanosomes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mitochondrial Proteins
/
Mitochondrial Membranes
Limits:
Animals
Language:
En
Journal:
Curr Opin Cell Biol
Year:
2022
Document type:
Article