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Design, synthesis and preclinical evaluation of bio-conjugated amylinomimetic peptides as long-acting amylin receptor agonists.
Patch, Raymond J; Zhang, Rui; Edavettal, Suzanne; Macielag, Mark J; Eckardt, Annette J; Li, Jiali; Rives, Marie-Laure; Edwards, Wilson; Hinke, Simon A; Qiu, Xi; Jian, Wenying; Libiger, Ondrej; Zheng, Songmao; Jeyaseelan, Jey; Liang, Yin; Rangwala, Shamina M; Leonard, James N; Hornby, Pamela.
Affiliation
  • Patch RJ; Janssen Research & Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA. Electronic address: rpatch2@its.jnj.com.
  • Zhang R; Janssen Research & Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA.
  • Edavettal S; Janssen Research & Development, LLC, 3210 Merryfield Row, La Jolla, CA, 92121, USA.
  • Macielag MJ; Janssen Research & Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA.
  • Eckardt AJ; Janssen Research & Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA.
  • Li J; Janssen Research & Development, LLC, 3210 Merryfield Row, La Jolla, CA, 92121, USA.
  • Rives ML; Janssen Research & Development, LLC, 3210 Merryfield Row, La Jolla, CA, 92121, USA.
  • Edwards W; Janssen Research & Development, LLC, 3210 Merryfield Row, La Jolla, CA, 92121, USA.
  • Hinke SA; Janssen Research & Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA.
  • Qiu X; Janssen Research & Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA.
  • Jian W; Janssen Research & Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA.
  • Libiger O; Janssen Research & Development, LLC, 3210 Merryfield Row, La Jolla, CA, 92121, USA.
  • Zheng S; Janssen Research & Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA.
  • Jeyaseelan J; Janssen Research & Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA.
  • Liang Y; Janssen Research & Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA.
  • Rangwala SM; Janssen Research & Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA.
  • Leonard JN; Janssen Research & Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA.
  • Hornby P; Janssen Research & Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA.
Eur J Med Chem ; 236: 114330, 2022 Jun 05.
Article in En | MEDLINE | ID: mdl-35436670
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Amylin Receptor Agonists Limits: Animals / Humans Language: En Journal: Eur J Med Chem Year: 2022 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Amylin Receptor Agonists Limits: Animals / Humans Language: En Journal: Eur J Med Chem Year: 2022 Document type: Article